Research use only. OSAConsensus is an integrated reanalysis resource for public obstructive sleep apnoea (OSA) and chronic intermittent hypoxia (CIH) transcriptomic data. Despite the name, it is not a clinical consensus statement or practice guideline and provides no diagnosis or treatment advice. Every program set carries its evidence-tier label; sets that failed cross-cohort or held-out validation are labelled as such next to the data.
Downloads
All frozen tables of the resource. Program-set files carry a tier/calibre column implementing the Step 7 adjudication: check it before citing any set. The per-gene cross-species response table (24,618 rows) is the entity of the cross-species bridge.
Global-shift warning: GSE135917's disease contrast is a global expression shift (47.3% of genes FDR-significant, median logFC −0.134). This set has FDR support in 0/1,408 genes in GSE38792 and is NOT a cross-cohort consensus (revoked in Step 7).
| File | Content | Tier |
|---|---|---|
| curation_table_frozen.csv | Frozen curation table — 34 series (Step 2) | |
| protocol_completion_table.csv | CIH protocol completion table with per-field sources (Step 2) | |
| program_P283.csv | P283 program, 121 genes, with calibre column | |
| program_NOM18.csv | NOM18 nominal set, 18 genes | |
| program_FAT_GSE135917_singlecohort.csv | GSE135917 single-cohort set, 1,408 genes (REVOKED as cross-cohort consensus) | |
| adenoid_programs_step4.csv | Adenoid program sets incl. NOMINAL 720 and FDR small sets (Step 4) | |
| consensus_hippocampus_mouse.csv | Mouse hippocampus consensus with tiers (Step 5) | |
| liver_sensitivity_set_46.csv | Mouse liver ≥3/4 sensitivity set, 46 genes (Step 5) | |
| per_gene_cross_species_response.csv | Per-gene cross-species response table, 24,618 rows (Step 6) | |
| pathway_fidelity_ranking.csv | Pathway fidelity ranking, 20 combinations — positional only (Step 6) | |
| pathway_concordance_matrix_long.csv | Pathway concordance matrix, long form (Step 6) | |
| evidence_matrix_blood.csv | Blood gene × cohort evidence matrix, 19,135 genes (Step 3) | |
| evidence_matrix_fat.csv | Adipose gene × cohort evidence matrix (Step 3; see F-06 calibre file) | |
| heldout_validation_summary.csv | Held-out validation summary — P283 & NOM18 in GSE293433 (Step 7) | |
| heldout_program_scores.csv | Held-out per-sample program scores, GSE293433 (Step 7) | |
| f06_fat_corrected_calibre.csv | F-06 adipose corrected-calibre list (Step 7) | |
| adjudication_table_H1_H22.csv | Grand adjudication table H1–H22 (Step 7) |
P283 download carries its calibre in-file: single-cohort FDR program; held-out validation failed and reversed (Step 7). Do not cite as a validated signature.